The CW has released the official guide for Season 7 of Supernatural.
Here’s what is coming up next season:

    The Winchesters will find themselves in an increasingly sinister, changing landscape, up against a new foe unlike anything they’ve ever fought.
    They’ll find their old tricks, weapons, and hiding places all rendered useless.
    All they’ll have is each other.  And the certainty that, like the last of the cowboy outlaws, whatever they face, they’re not going down without a fight.

We already know that Supernatural star Jensen Ackles will be returning to the director's chair in season 7, taking control of the third episode (airing October 7), but now we know a lot more about what that episode will be. According to Zap2It, the Ackles-directed episode, currently titled "The Girl Next Door," will focus on Sam's past with a girl named Amy.

The story will also feature flashbacks starring Colin Ford as young Sam, who we've seen in four previous episodes. However, currently it seems we won't be seeing young Dean in the episode, though the actor who plays him, Brock Kelly, is in talks to return at some point later in season 7.

"The Girl Next Door" will center on Sam reconnecting with Amy, a girl who saved his life when he was 15 and who wanted him to run away with her. Now she's settled and living a normal life with a kid, which makes her sound a bit like Sam's version of Lisa. It's probably safe to assume that if Sam is back in her life, it's about to get a lot less normal.

Last season Jensen Ackles directed his first episode, "Weekend at Bobby's," which also centered primarily on a non-Dean character. With Ackles behind the camera, it's safe to assume that Dean will be taking a backseat to Sam's storyline in this episode.